Well since we're on the "comparisons" lately with Fallout(s) to Skyrim's lovely foe's, I'll bring you this. ( Ugh,I'm so dry on topics, thought I would throw something out there for the community)
Oooo....Not sure about that. lol It would be a tough battle! Especially these two in the picture. Not the Super Mutants with the flame thrower or the mini-gun (can't remember that heavy machine guns name. I think it was called the mini-gun.)
Depends. Is the mutant a behemoth like the one in the picture? If it is, the giant is screwed. I mean, the behemoth can survive being hit by a NUKE. A mini nuke, anyway. A regular super mutant? He'd get owned.