It looks like its only going to be a matter of time before we get to see this video for ourselves! Some great details emerging about how you can shape your character from the very start of the game and the combat and encounters sound amazing!
It looks like the voiced protagonist idea overlaps into general gameplay, just inspecting objects or arriving at a new location is going to have your character muttering various comments, probably along the lines of the behavior of companions in Skyrim...
"Look a cave, wonder what's inside'
We saw a little of this when the character leaves the vault for the first time and has a small panic attack when he sees whats become of the world outside. Will this ruin immersion for some of you? I guess it depends how 'cool' the protagonist is, if your character starts making nervous comments when you're trying to RP as a seasoned war-vet I can imagine how it could be jolting, maybe we can turn it off...
Radiation is more deadly and will put a semi-permanent dampener on your health bar when you have radiation sickness which reminds me a little of playing Dark Souls with stunted health. Melee is also sounding very viable and fun in this game and the ability to surgically amputate limbs using VATS is definitely going to ensure we see some nice ninja builds here on the site...
The mass battles sound insane! I'm useless when it comes to anything that relies on very good hand eye co-ordination, so I'll probably be taking a back seat at those points
I'm pleased that melee sounds viable, and look forward to experiencing the new critical attacks. I'm currently re-playing Fallout 3 with a melee only character so I'm going to be definitely wanting to see a really good melee build here on the site.
The comments by the player character? Let's see how it plays out. I don't think it will bother me, but I can see how some people are going to hate on it.