July 15, 2013 11:20 PM EDT
Skelter Helter's Revolver- No More Heroes 2. Its a machine gun revolver!
Medicene Stick- FNV, GRA DLC. A badass repeater, and strong as hell. And FIDO from FNV OWB DLC.
For a melee...any BFS is eh-ok! (its a TV Tropes thing)