April 6, 2013 3:32 PM EDT
Most guilds could use a hand or two. The Companions, although good NPCs, has got a quite short, not too deep questline. Maybe there could be quests regarding ancient companions, where Kodlak would give us info from the ancient dead (I don't want to post spoilers, that's why I'm not mentioning certain detail), and even go to Sovngarde to see previous masters.
The College has a few questions to answer, like those involving the Psyjic order, the Synod and the Eye of Magnus. A trip to their island, maybe?
Dark brotherhood we could see from other provinces, like Hammerfell associates, either way (if we've destroyed or joined the DB), and maybe add Morag Tong to the mix.
Thieves' guild I don't see many paths, it was great itself but I have no idea how they'd continue.
DLC guilds I highly doubt they'd get updates, as not everyone has them. But it'd be nice to meet new vampire hunters that are mercenaries, and vampires from other provinces, with other abilities. Of course, you'd meet both either faction you joined. I just can imagine an Argonian or someone in some dark armor, a sword and a crossbow travelling along the road in search for blood-drinkers!
Although not guilds, it'd be nice to see more quests involving imperials and stormcloaks, aside from the civil war.
Or even we could see guilds MEET, maybe as an aid for you in a war, or for some reason. I just think there are many possibilities that Beth should explore. Like old projects like the Arena in Windhelm, or the ideas given in this topic.