February 3, 2016 3:54 AM EST
Wherever it will be set, there will be some version of a warrior guild and a mage guild, and all of the individual thieves guilds aren't really related, so one will probably return. The dark brotherhood however, will almost certainly not return, as just the fact that you can destroy them in the game means that they've most likely been destroyed for good. This doesn't mean that there won't be an assassin's guild of course, it just means that it won't be the dark brotherhood.