Spellsword is definitely a nice one. Very flexible. Probably my most used weapon set. It can work with any type of armor as well.
I also like just a one-handed sword, like Miraak, with nothing in the offhand. It affords a light, quick duelist style, with capability for blocking and bashing as needed. Best suited to a lightly armored or unarmored character.
Unarmed is also fun. Gotta say, I loved switching between the Bound Bow and Khajiit claws on the Regulator. It was great because both styles are effective in their own ways, and they can benefit from a lot of the same tactics/buffs. Plus, you can keep your BB spell in the left hand, and your right claw empty. So quick to summon/dispell the bow at will. No need for hotkeys, left alone the favorites menu.
Sword/dagger can be fun; I'm not generally a fan of dual-wielding, but if I do dual-wield that's probably my go-to combo.
I'd like to tinker with sword/staff, but haven't found the right combo for my tastes.
Not really a big fan of shields tbh; I don't think I've dedicated much time with them beyond my very first Skyrim character.